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Related Experiment Videos

Amlodipine in angina pectoris: effect on maximal and submaximal exercise performance.

D R Kinnard1, M Harris, K F Hossack

  • 1Department of Medicine, University of Colorado Health Sciences Center, Denver.

Journal of Cardiovascular Pharmacology
|January 1, 1988
PubMed
Summary

Amlodipine, a calcium channel blocker, significantly reduced angina symptoms and nitroglycerin use in patients with angina. It also improved exercise capacity, demonstrating its efficacy and tolerability.

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Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Angina pectoris is a common condition characterized by chest pain due to reduced blood flow to the heart.
  • Dihydropyridine calcium antagonists are a class of drugs used to treat cardiovascular conditions.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of amlodipine in patients with angina.
  • To compare amlodipine with placebo in a double-blind crossover study.

Main Methods:

  • 16 patients with angina participated in a double-blind crossover study.
  • Patients alternated between 4 weeks of amlodipine (10 mg daily) and 4 weeks of placebo.
  • Efficacy was assessed by angina frequency, nitroglycerin consumption, and exercise test parameters.

Main Results:

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  • Amlodipine significantly reduced nitroglycerin consumption compared to placebo.
  • Both amlodipine and placebo reduced angina frequency compared to the initial single-blind placebo period.
  • Amlodipine significantly increased peak oxygen consumption and exercise endurance time.

Conclusions:

  • Amlodipine is effective in improving exercise capacity and reducing anginal symptoms and nitroglycerin use in patients with angina.
  • Amlodipine was well-tolerated by patients, with no significant side effects observed.