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Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
Primary malignant cardiac tumors
Lei Yu1, Tianxiang Gu, Enyi Shi
1Department of Cardiac Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.
Purpose:
The literature on primary malignant cardiac tumors is relatively limited because of their rare incidence. This study aimed to provide a proposed treatment strategy for primary malignant cardiac tumors.
Methods:
The follow-up outcomes of 29 patients with primary malignant cardiac tumors operated, and 8 primary malignant cardiac tumors considered not operable from 1985 to 2013 in the First Affiliated Hospital of China Medical University were retrospectively analyzed.
Results:
Of operation receivers, ten patients had positive surgical margins and nineteen patients had negative surgical margins. Eleven patients received a post-operative neoadjuvant chemotherapy. Patients rejected to surgery had a lower survival compared with operation receivers (15 vs 23 months, P = 0.011). However, there were no significant differences in survival in patients rejected to surgery than in patients who had positive surgical margins (15 vs 16 months, P = 0.874). Patients who had positive surgical margins had a median overall survival duration of only 16 months, whereas patients with negative surgical margins had a median overall survival duration of 27 months (P = 0.002). There were no significant differences in survival in patients with receiving a post-operative adjuvant chemotherapy than in the rest of the population (20 vs 25 months, P = 0.150).
Conclusions:
The prognosis for patients with primary malignant cardiac tumors remains very poor. Each patient should be managed on an individual basis, and variety of treatment strategy should be performed. Maximizing the possibility of obtaining negative surgical margins may prolong survival.
Insights
Primary malignant cardiac tumors have a poor prognosis. Achieving negative surgical margins is crucial for improving survival in these rare heart cancers. Individualized treatment strategies are recommended.
Area of Science:
- Cardiology
- Oncology
- Surgical Oncology
Background:
- Primary malignant cardiac tumors are rare, with limited existing literature.
- Their rarity necessitates a deeper understanding of treatment strategies and outcomes.
Purpose of the Study:
- To propose a treatment strategy for primary malignant cardiac tumors.
- To analyze outcomes based on surgical intervention and margin status.
Main Methods:
- Retrospective analysis of 29 operated and 8 inoperable primary malignant cardiac tumor cases (1985-2013).
- Evaluation of patient survival based on surgical margins and adjuvant therapies.
Main Results:
- Patients undergoing surgery had better survival (23 months) than those rejected (15 months).
- Negative surgical margins (27 months) significantly improved survival compared to positive margins (16 months).
- Post-operative chemotherapy did not show a significant survival benefit.
Conclusions:
- Prognosis for primary malignant cardiac tumors remains poor.
- Individualized treatment and maximizing negative surgical margins are key for survival.
- Further research into tailored treatment strategies is warranted.
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