Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

826
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
826
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

16.8K
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
16.8K
Tumor Progression02:07

Tumor Progression

6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
Metastasis02:30

Metastasis

5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

805
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
805
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

6.7K
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Facile Synthesis of Biocompatible Fluorescent Nanoparticles for Cellular Imaging and Targeted Detection of Cancer Cells.

ACS applied materials & interfaces·2015
Same author

Item exposure control for multidimensional computer adaptive testing under maximum likelihood and expected a posteriori estimation.

Behavior research methods·2015
Same author

[Electric-heat needling for 56 cases of cervical spondylosis with the neck type].

Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2015
Same author

[Effects of GLP-1 Agonist Exenatide on Cardiac Diastolic Function and Vascular Endothelial Function in Diabetic Patients].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition·2015
Same author

Evaluation of The Cervista HPV A9 group In Screening Patients for Cervical Cancer.

Journal of medical screening·2015
Same author

Porous carbon derived from a metal-organic framework as an efficient adsorbent for the solid-phase extraction of phthalate esters.

Journal of separation science·2015

Related Experiment Video

Updated: May 1, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

1.6K

Primary malignant cardiac tumors.

Lei Yu1, Tianxiang Gu, Enyi Shi

  • 1Department of Cardiac Surgery, The First Affiliated Hospital of China Medical University, Shenyang, 110001, People's Republic of China.

Journal of Cancer Research and Clinical Oncology
|March 28, 2014
PubMed
Summary

Primary malignant cardiac tumors have a poor prognosis. Achieving negative surgical margins is crucial for improving survival in these rare heart cancers. Individualized treatment strategies are recommended.

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K

Related Experiment Videos

Last Updated: May 1, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
08:01

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines

Published on: April 21, 2022

1.6K
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K

Area of Science:

  • Cardiology
  • Oncology
  • Surgical Oncology

Background:

  • Primary malignant cardiac tumors are rare, with limited existing literature.
  • Their rarity necessitates a deeper understanding of treatment strategies and outcomes.

Purpose of the Study:

  • To propose a treatment strategy for primary malignant cardiac tumors.
  • To analyze outcomes based on surgical intervention and margin status.

Main Methods:

  • Retrospective analysis of 29 operated and 8 inoperable primary malignant cardiac tumor cases (1985-2013).
  • Evaluation of patient survival based on surgical margins and adjuvant therapies.

Main Results:

  • Patients undergoing surgery had better survival (23 months) than those rejected (15 months).
  • Negative surgical margins (27 months) significantly improved survival compared to positive margins (16 months).
  • Post-operative chemotherapy did not show a significant survival benefit.

Conclusions:

  • Prognosis for primary malignant cardiac tumors remains poor.
  • Individualized treatment and maximizing negative surgical margins are key for survival.
  • Further research into tailored treatment strategies is warranted.