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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
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The effects of flavonoids on bone.

Ailsa A Welch1, Antonia C Hardcastle

  • 1Department of Population Health and Primary Care, Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK, a.welch@uea.ac.uk.

Current Osteoporosis Reports
|March 28, 2014
PubMed
Summary

Dietary flavonoids from fruits and vegetables show promise in protecting bone health and may reduce osteoporosis risk. Further research is needed to confirm these benefits for bone mineral density.

Area of Science:

  • Nutritional Science
  • Bone Biology
  • Gerontology

Background:

  • Osteoporosis and fragility fractures pose a significant health risk to the aging population.
  • Established fracture risk reduction strategies include physical activity, smoking cessation, and adequate vitamin D and calcium intake.
  • Dietary mechanisms, particularly the role of flavonoids, are less understood in bone health.

Purpose of the Study:

  • To investigate the potential role of dietary flavonoids in bone health.
  • To explore the association between flavonoid intake and bone mineral density.
  • To identify areas for future research in flavonoid and bone metabolism.

Main Methods:

  • Review of existing human epidemiologic studies, focusing on two studies in women.

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  • Analysis of associations between total dietary flavonoid intake and bone mineral density.
  • Exploration of potential biological mechanisms of flavonoid action on bone.

    • Main Results:

    • Two human epidemiologic studies indicated a positive association between total dietary flavonoid intake and bone mineral density in women.
    • Potential mechanisms include upregulation of osteoblast function, reduction of oxidative stress, and mitigation of chronic low-grade inflammation.

    Conclusions:

    • Dietary flavonoids represent a promising area for research in preventing bone loss and osteoporosis.
    • Further investigation is warranted to elucidate the specific mechanisms and confirm the benefits of flavonoids for bone health.