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Antitussive drugs--past, present, and future.

P V Dicpinigaitis¹, A H Morice, S S Birring

¹King's College London, Franklin Wilkins Building, 100 Stamford St., London, SE1 9NH, UK. clive.page@kcl.ac.uk.

Pharmacological Reviews

|March 28, 2014

Summary

This summary is machine-generated.

Cough is a common symptom of many diseases, but effective treatments are limited. Recent advances in understanding the cough reflex offer hope for developing new antitussive drugs.

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Area of Science:

Pulmonology
Pharmacology

Background:

Cough is a significant clinical issue, appearing as a symptom of conditions like asthma and COPD, or as a primary condition (chronic cough).
Current antitussive therapies and commonly used cough treatments lack robust clinical evidence, especially over-the-counter options.

Purpose of the Study:

To review the current understanding of cough pathogenesis and the hyper-tussive state.
To evaluate the evidence for existing antitussive drug classes and other commonly used cough medications.
To discuss novel antitussive drug classes in development.

Main Methods:

Literature review of existing antitussive drugs and drug classes.
Examination of evidence for drugs used to treat cough, including those not classified as antitussives.
Review of emerging antitussive drug candidates.

Main Results:

Evidence supporting many current antitussive drug classes, particularly OTC options, is limited.
Significant progress has been made in understanding the cough reflex over the past decade.

Conclusions:

There is a need for more well-controlled clinical studies to validate current cough treatments.
New therapeutic targets for antitussive drugs have been identified, offering potential for future treatments.