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Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States
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Fibrin clot properties and their modulation in thrombotic disorders
1Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St., 31-202 Krakow, Poland, Tel.: +48 12 6143004, Fax: +48 12 4233900,
Thrombosis and Haemostasis
|March 28, 2014
Summary
Patients with thrombosis often have fibrin clots that are resistant to breakdown. This review examines clot structure, function, and factors influencing these changes in thromboembolic disorders.
Area of Science:
- Biochemistry
- Hematology
- Pathophysiology
Background:
- Accelerated fibrin clot formation is linked to thrombosis.
- These clots often feature compact, branched networks of thin fibers.
- Such structures exhibit resistance to plasmin-mediated lysis.
Purpose of the Study:
- To review fibrin clot structure and function in thromboembolic disorders.
- To identify factors influencing altered clot properties in vivo.
- To discuss potential therapeutic modalities for improving clot phenotype.
Main Methods:
- Literature review of publications up to December 2013.
- Analysis of fibrin clot characteristics in various thromboembolic conditions.
- Identification of factors affecting fibrin clot properties in vivo.
Main Results:
- Thrombotic disorders are associated with specific fibrin clot structures.
- Altered clot structure impacts resistance to lysis.
- Various in vivo factors contribute to unfavorable clot phenotypes.
Conclusions:
- Fibrin clot characteristics are crucial in thromboembolic manifestations.
- Understanding factors influencing clot phenotype can guide therapeutic strategies.
- Targeting clot properties may offer new treatment avenues for thrombosis.
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