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Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth
F Ishikawa1, K Miyazono, U Hellman
1Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
Nature
|April 13, 1989
Abstract:
Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.