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Olmesartan and drug-induced enteropathy
P & T : a Peer-Reviewed Journal for Formulary Management
|March 28, 2014
Summary
Olmesartan (Benicar) can cause sprue-like symptoms in some patients. Withholding this medication led to symptom improvement in three reported cases, suggesting a potential drug-induced condition.
Area of Science:
- Gastroenterology
- Pharmacology
Background:
- Sprue-like symptoms, characterized by malabsorption and diarrhea, can have various etiologies.
- Olmesartan is an angiotensin II receptor blocker commonly prescribed for hypertension.
Purpose of the Study:
- To report three cases where sprue-like symptoms were potentially induced by olmesartan therapy.
- To highlight the importance of considering medication side effects in the differential diagnosis of sprue-like enteropathy.
Main Methods:
- Case series review of three patients presenting with sprue-like symptoms.
- Detailed medical history, including medication review, and clinical follow-up after olmesartan withdrawal.
Main Results:
- All three patients experienced significant improvement in their sprue-like symptoms after discontinuing olmesartan.
- No alternative causes for the enteropathy were identified in these cases.
Conclusions:
- Olmesartan therapy may be associated with the development of sprue-like symptoms in susceptible individuals.
- Discontinuation of olmesartan can lead to resolution of these gastrointestinal adverse effects.
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