Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

10.6K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.6K
Antimicrobial Proteins01:23

Antimicrobial Proteins

10.6K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
10.6K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

3.0K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
3.0K
Antibody Actions01:26

Antibody Actions

3.9K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
3.9K
Hypersensitivity Reactions: Cytolytic Reactions01:01

Hypersensitivity Reactions: Cytolytic Reactions

208
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
208
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

10.9K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of an interdisciplinary process to increase utilization of neuraxial anesthesia for cesarean delivery: a retrospective database analysis.

International journal of obstetric anesthesia·2024
Same author

Fungal Planet description sheets: 1284-1382.

Persoonia·2023
Same author

Fungal Planet description sheets: 1042-1111.

Persoonia·2020
Same author

Fungal Planet description sheets: 951-1041.

Persoonia·2020
Same author

Older Donation After Circulatory Death Kidneys for Older Recipients: A Single-Center Experience.

Transplantation proceedings·2019
Same author

Dual Kidney Transplantation Offers a Valuable Source for Kidneys With Good Functional Outcome.

Transplantation proceedings·2016
Same journal

Head-to-head evaluation of a commercial real-time PCR assay targeting plasmodial species causing human malaria against a composite reference standard.

European journal of microbiology & immunology·2026
Same journal

Therapeutic effects of Lentinan in gastrointestinal inflammation and carcinogenesis - A scoping review of evidence from preclinical and clinical studies.

European journal of microbiology & immunology·2026
Same journal

Comprehensive analyses of pathogen loads and immune responses alongside the gastrointestinal tract upon long-term Salmonella Typhimurium-infection of clinically resistant mice.

European journal of microbiology & immunology·2026
Same journal

Microbiome of the Eustachian tube in patients with chronic obstructive Eustachian tube dysfunction and healthy individuals.

European journal of microbiology & immunology·2026
Same journal

Changes in hand hygiene compliance and technique among non-healthcare professionals in a tertiary-care hospital: Before and during the COVID-19 pandemic.

European journal of microbiology & immunology·2026
Same journal

A bibliometric analysis of global research on plant-derived antimicrobials targeting Methicillin-resistant Staphylococcus aureus (2004-2024).

European journal of microbiology & immunology·2026
See all related articles

Related Experiment Video

Updated: May 1, 2026

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

23.1K

The complement system: history, pathways, cascade and inhibitors.

P N Nesargikar, B Spiller, R Chavez

    European Journal of Microbiology & Immunology
    |March 28, 2014
    PubMed
    Summary
    This summary is machine-generated.

    The complement system, discovered in the 19th century, is clinically significant in various conditions like autoimmune diseases and transplant injury. This review covers its history, activation pathways, and regulators.

    Keywords:
    complement activationcomplement cascadecomplement historycomplement inhibitorscomplement system

    More Related Videos

    Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
    06:54

    Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

    Published on: June 15, 2019

    5.3K
    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
    07:26

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

    Published on: July 18, 2017

    12.4K

    Related Experiment Videos

    Last Updated: May 1, 2026

    Depletion of Specific Cell Populations by Complement Depletion
    06:17

    Depletion of Specific Cell Populations by Complement Depletion

    Published on: February 5, 2010

    23.1K
    Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
    06:54

    Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

    Published on: June 15, 2019

    5.3K
    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
    07:26

    High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

    Published on: July 18, 2017

    12.4K

    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • The complement system is a critical part of the innate immune system.
    • It plays a role in host defense, inflammation, and clearance of immune complexes.
    • Dysregulation is linked to numerous diseases.

    Purpose of the Study:

    • To provide a historical overview of the complement system's discovery and evolution.
    • To summarize the key activation pathways of the complement cascade.
    • To discuss the regulatory mechanisms that control complement activity.

    Main Methods:

    • Literature review of historical and contemporary research on the complement system.
    • Synthesis of information on complement activation pathways (classical, lectin, alternative).
    • Analysis of known complement regulatory proteins and their functions.

    Main Results:

    • The complement system has a rich history dating back to the 19th century.
    • Three main pathways converge to activate the complement cascade.
    • A complex network of regulators prevents self-damage.

    Conclusions:

    • The complement system is a vital and complex immunological entity.
    • Understanding its pathways and regulation is crucial for clinical applications.
    • Further research continues to uncover its multifaceted roles in health and disease.