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Related Experiment Video

Updated: May 1, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Left atrial appendage exclusion-Where do we stand?

Timothy Sakellaridis1, Mihalis Argiriou1, Christos Charitos1

  • 11 Cardiac Surgery Department, "Evangelismos" General Hospital, Athens, Greece ; 2 Cardiothoracic Surgery Department, "Saint Luke" Private Hospital, Thessaloniki, Panorama, Greece ; 3 Pulmonary Department-Oncology Unit, "G. Papanikolaou" General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece ; 4 Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece ; 5 Internal Medicine Department, "Theageneio" Anticancer Hospital, Thessaloniki, Greece ; 6 Cardiology Department, "Saint" Luke Private Hospital, Thessaloniki, Panorama, Greece ; 7 Anesthisiology Department, "Saint" Luke Private Hospital, Thessaloniki, Panorama, Greece.

Journal of Thoracic Disease
|March 28, 2014
PubMed
Summary
This summary is machine-generated.

Left atrial appendage (LAA) exclusion offers an alternative stroke prevention method for patients with atrial fibrillation (AF) unsuitable for oral anticoagulation. Mechanical LAA closure demonstrates feasibility and efficacy in preventing thromboembolic events.

Keywords:
Left atrial appendage (LAA)atrial fibrillation (AF)device implantationexclusionligationoral anticoagulation (OAC)

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Area of Science:

  • Cardiology
  • Vascular Surgery

Background:

  • Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with a high risk of stroke, primarily from left atrial appendage (LAA) thrombi.
  • Oral anticoagulation (OAC) with vitamin-K antagonists is standard for stroke prevention but has contraindications and limitations for many AF patients.

Purpose of the Study:

  • To review the evidence and results of mechanical left atrial appendage (LAA) exclusion as an alternative to OAC for stroke prevention in patients with non-valvular AF.

Main Methods:

  • Review of current evidence on LAA exclusion techniques, including surgical, thoracoscopic, and percutaneous transcatheter approaches.
  • Analysis of studies evaluating dedicated LAA exclusion devices like PLAATO, Watchman, and Amplatzer cardiac plug.

Main Results:

  • Percutaneous transcatheter LAA exclusion devices show encouraging feasibility and efficacy.
  • High rates of successful implantation have been reported for these devices.
  • LAA exclusion serves as a viable alternative to OAC for selected AF patients.

Conclusions:

  • Mechanical LAA exclusion is an effective strategy for preventing thromboembolic events in AF patients.
  • Transcatheter LAA occlusion devices offer a promising alternative for patients who cannot tolerate or benefit from OAC.