Reference Ranges for Serum Uric Acid among Healthy Assamese People

Area of Science:

• Clinical Biochemistry
• Human Physiology
• Population Health Studies

Background:

• Serum uric acid levels are critical indicators of metabolic health.
• Existing reference ranges may not accurately reflect diverse populations.
• Establishing population-specific ranges is essential for accurate diagnosis.

Purpose of the Study:

• To determine age and sex-specific reference ranges for serum uric acid in the healthy adult Assamese population.
• To compare these new ranges with existing laboratory standards.
• To investigate the relationship between serum uric acid and demographic factors.

Main Methods:

• A cross-sectional study involving 1470 healthy adults aged 35-86 years from the Assamese population.
• Serum uric acid levels were measured using standardized laboratory techniques.
• Reference ranges were established using the centile method (central 95th percentile).

Main Results:

• The established reference range for serum uric acid in this population is 2.6-8.2 mg/dL.
• This observed range is significantly wider than the current laboratory reference range.
• A statistically significant difference in mean serum uric acid levels was found between males and females (P < 0.0001).

Conclusions:

• The study provides a more accurate, population-specific reference range for serum uric acid in the Assamese adult population.
• The findings suggest a need to re-evaluate current laboratory reference ranges for this demographic.
• Gender is a significant factor influencing serum uric acid levels in this population.