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Related Concept Videos

Influenza01:27

Influenza

87
Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
87
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

14.1K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
14.1K

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Modeling Dysplastic and Functional Lung Alveolar Repair after Influenza Infection
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Does influenza A infection increase oxidative damage?

Mary P E Ng1, Jetty C Y Lee, Wai Mun Loke

  • 11 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, Singapore .

Antioxidants & Redox Signaling
|March 29, 2014
PubMed
Summary
This summary is machine-generated.

Oxidative damage, measured by biomarkers like F2-isoprostanes, is elevated during acute influenza and persists post-infection. This damage may contribute to ongoing symptoms such as fatigue and pain.

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Area of Science:

  • Biochemistry
  • Immunology
  • Pathogenesis

Background:

  • Oxidative damage is increasingly implicated in the pathogenesis of various infections, including influenza.
  • Understanding the temporal dynamics of oxidative stress markers during and after influenza is crucial for elucidating disease mechanisms.

Purpose of the Study:

  • To investigate temporal changes in oxidative damage biomarkers in adult influenza A patients.
  • To correlate these oxidative damage markers with clinical parameters and persistent post-influenza symptoms.

Main Methods:

  • Prospective cohort study of 35 adult influenza A patients.
  • Collection of clinical data and blood samples during acute illness and at 3-month follow-up.
  • Measurement of plasma F2-isoprostanes, total hydroxyeicosatetraenoic products (HETEs), cholesterol oxidation products, gamma-glutamyltransferase, and high-sensitivity C-reactive protein (hsCRP).
  • Administration of a fatigue questionnaire at 3-month follow-up.

Main Results:

  • Influenza patients showed significantly increased levels of multiple oxidative damage biomarkers during acute illness compared to controls.
  • Elevated biomarker levels persisted at 3 months post-infection, despite clinical recovery.
  • Patients with persistent fatigue had higher baseline F2-isoprostanes and HETEs.
  • Patients with persistent myalgia and arthralgia had higher baseline hsCRP.

Conclusions:

  • Oxidative damage is a significant feature of acute influenza infection and can persist beyond clinical recovery.
  • Persistent oxidative stress may play a role in the development of post-influenza symptoms, particularly fatigue and musculoskeletal pain.
  • These findings support a hypothesis linking oxidative damage to influenza pathogenesis and post-infectious sequelae.