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Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma
Lei Wang1, Tianwen Gao, Gang Wang
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.
Background:
Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.
Methods:
We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).
Results:
The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.
Conclusion:
Our results suggest that spindle cell hemangioma is a lymphatic malformation.
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