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Relative immaturity and ADHD: findings from nationwide registers, parent- and self-reports
Linda Halldner1, Annika Tillander, Cecilia Lundholm
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Karolinska Institutet Center of Neurodevelopmental Disorders (KIND), Karolinska Institutet, Stockholm, Sweden.
Insights
Children born in late autumn are more likely to be diagnosed with and treated for Attention Deficit Hyperactivity Disorder (ADHD) due to relative immaturity. This diagnosis pattern for ADHD was not supported by symptom ratings.
Area of Science:
- Child and Adolescent Psychiatry
- Neurodevelopmental Disorders
- Public Health Research
Background:
- Investigated the link between birth month, relative immaturity, and Attention Deficit Hyperactivity Disorder (ADHD) diagnosis and treatment.
- Explored potential biases in ADHD diagnosis stemming from age-related differences within school cohorts.
Purpose of the Study:
- To determine if being younger relative to classmates, indicated by birth month, increases the likelihood of an ADHD diagnosis and subsequent treatment.
- To examine the association between birth month and ADHD symptom severity in different age groups.
Main Methods:
- Utilized Swedish nationwide registers (Patient and Prescribed Drug Registers) for a large cohort (N=56,263) aged 6-69 years.
- Employed prospective cohort and nested case-control designs, analyzing ADHD diagnoses and medication use.
- Supplemented with population-representative twin cohorts (CATSS and STAGE) for parent- and self-reported ADHD symptoms.
Main Results:
- Individuals born in November/December showed significantly higher rates of ADHD diagnosis and medication treatment compared to those born in January/February.
- This diagnostic and treatment disparity peaked at ages 6 and 7 years.
- No significant differences in parent- or self-reported ADHD symptoms were found based on birth month.
Conclusions:
- Relative immaturity due to birth month may contribute to ADHD diagnosis and pharmacotherapy, independent of actual symptom load.
- Highlights the need for increased clinical awareness to prevent diagnostic and treatment inaccuracies.
- Suggests that flexible school entry age policies could improve diagnostic precision and reduce inappropriate ADHD treatment.
Background:
We addressed if immaturity relative to peers reflected in birth month increases the likelihood of ADHD diagnosis and treatment.
Methods:
We linked nationwide Patient and Prescribed Drug Registers and used prospective cohort and nested case-control designs to study 6-69 year-old individuals in Sweden from July 2005 to December 2009 (Cohort 1). Cohort 1 included 56,263 individuals diagnosed with ADHD or ever used prescribed ADHD-specific medication. Complementary population-representative cohorts provided DSM-IV ADHD symptom ratings; parent-reported for 10,760 9-year-old twins born 1995-2000 from the CATSS study (Cohort 2) and self-reported for 6,970 adult twins age 20-47 years born 1959-1970 from the STAGE study (Cohort 3). We calculated odds ratios (OR:s) for ADHD across age for individuals born in November/December compared to January/February (Cohort 1). ADHD symptoms in Cohorts 2 and 3 were studied as a function of calendar birth month.
Results:
ADHD diagnoses and medication treatment were both significantly more common in individuals born in November/December versus January/February; peaking at ages 6 (OR: 1.8; 95% CI: 1.5-2.2) and 7 years (OR: 1.6; 95% CI: 1.3-1.8) in the Patient and Prescribed Drug Registers, respectively. We found no corresponding differences in parent- or self-reported ADHD symptoms by calendar birth month.
Conclusion:
Relative immaturity compared to class mates might contribute to ADHD diagnosis and pharmacotherapy despite absence of parallel findings in reported ADHD symptom loads by relative immaturity. Increased clinical awareness of this phenomenon may be warranted to decrease risk for imprecise diagnostics and treatment. We speculate that flexibility regarding age at school start according to individual maturity could reduce developmentally inappropriate demands on children and improve the precision of ADHD diagnostic practice and pharmacological treatment.
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