Peripheral brain derived neurotrophic factor (BDNF) in bulimia nervosa: a systematic review
Kathryn Phillips1, Kathleen Keane2, Barbara E Wolfe3
1Fairfield University, Fairfield, CT.
Introduction:
Currently, there is limited understanding of the etiology of BN. While multifaceted etiology is likely, several neurobiological factors may play a role. Brain derived neurotrophic factor (BDNF), a potential biomarker linked to eating and weight disorders, is one factor of recent investigation. This paper examined studies comparing BDNF blood levels in BN to healthy control (HC) subjects.
Methods:
A systematic review of the literature was conducted utilizing five databases (PubMed, CINAHL, EMBASE, PsycINFO, and Medline). Key terms included eating disorders, BDNF, and bulimia nervosa.
Conclusions:
BDNF blood levels appear lower in BN than in HC subjects; however, studies are needed to examine the influence of possible correlates including symptom severity, mood, medications, exercise, and substance use.
Related Concept Videos
Bulimia Nervosa
Binge Eating Disorders
Anorexia Nervosa
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
Regulation of Food Intake


