Related Experiment Videos
Fluid flow stimulates tissue plasminogen activator secretion by cultured human endothelial cells
S L Diamond1, S G Eskin, L V McIntire
1Rice University, Biomedical Engineering Laboratory, Houston, TX 77251.
Science (New York, N.Y.)
|March 17, 1989
Abstract:
Wall shear stress generated by blood flow may regulate the expression of fibrinolytic proteins by endothelial cells. Tissue plasminogen activator (tPA) and plasminogen activator inhibitor, type 1 (PAI-1) secretion by cultured human endothelial cells were not affected by exposure to venous shear stress (4 dynes/cm2). However, at arterial shear stresses of 15 and 25 dynes/cm2, the tPA secretion rate was 2.1 and 3.0 times greater, respectively, than the basal tPA secretion rate. PAI-1 secretion was unaffected by shear stress over the entire physiological range.