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Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Stereotactic radiotherapy for pulmonary metastases.

Steven J Chmura1, Joseph K Salama2, Ralph R Weichselbaum3

  • 1Ludwig Center for Metastasis Research, University of Chicago, Chicago, Illinois.

Seminars in Thoracic and Cardiovascular Surgery
|March 29, 2014
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Summary

High-dose stereotactic body radiation therapy shows promise for treating limited pulmonary metastases from solid tumors. Ongoing trials compare this aggressive local control against standard palliative care for improved survival.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Medical Physics

Background:

  • Pulmonary metastases from solid tumors are commonly treated with systemic therapies.
  • Surgical resection of lung metastases has shown potential benefits in select cases.
  • Emerging evidence supports aggressive local control for limited or oligometastatic disease.

Purpose of the Study:

  • To review the role of ablative radiotherapy in treating pulmonary metastases.
  • To discuss the rationale, delivery, and local control of stereotactic body radiation therapy (SBRT).
  • To highlight ongoing randomized trials evaluating SBRT against standard care.

Main Methods:

  • Review of clinical trials and retrospective series on pulmonary metastases treatment.
  • Focus on high-conformal dose radiotherapy, specifically SBRT.
  • Discussion of treatment delivery techniques and local control data.

Main Results:

  • SBRT is increasingly supported for limited pulmonary metastases and oligometastases.
  • Patients with limited metastases may represent a distinct clinical and biological subgroup.
  • Data suggest SBRT offers effective local control.

Conclusions:

  • Ablative radiotherapy, particularly SBRT, is a promising treatment modality for pulmonary metastases.
  • Ongoing randomized trials aim to establish SBRT's benefit over palliative care.
  • Further research is needed to define the optimal role of SBRT in managing lung metastases.