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Related Experiment Videos

Heparin and bleeding: an association with lipase release.

T W Barrowcliffe1, R E Merton, E Gray

  • 1National Institute for Biological Standards and Control, London, UK.

Thrombosis and Haemostasis
|December 22, 1988
PubMed
Summary

Unfractionated heparin and pentosan polysulphate significantly prolonged bleeding times and increased lipase release in rabbits. These effects on bleeding and lipase release are linked to specific structural features of sulphated polysaccharides.

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Area of Science:

  • Pharmacology
  • Biochemistry

Background:

  • Sulphated polysaccharides are known to affect various physiological processes.
  • Heparin and its derivatives are widely used anticoagulants with diverse biological activities.

Purpose of the Study:

  • To compare the effects of four different sulphated polysaccharides on bleeding time and lipase release.
  • To investigate the relationship between bleeding time and lipase release induced by these compounds.

Main Methods:

  • In vivo study in rabbits.
  • Administration of unfractionated heparin, low molecular weight heparin, pentosan polysulphate, and dermatan sulphate.
  • Measurement of bleeding time and assessment of lipase release.

Main Results:

Related Experiment Videos

  • Unfractionated heparin and pentosan polysulphate significantly increased bleeding time and lipase release.
  • Low molecular weight heparin showed reduced effects on both parameters.
  • Dermatan sulphate had no significant effect on bleeding time or lipase release.
  • A strong positive correlation (r = 0.97) was observed between bleeding time and lipase release.

    • Conclusions:

    • The structural characteristics of sulphated polysaccharides dictate their influence on both haemorrhagic and lipase-releasing properties.
    • These findings suggest a common mechanism underlying the effects of certain sulphated polysaccharides on hemostasis and lipolysis.