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Radiation therapy for optic nerve sheath meningioma
Jeffrey V Brower1, Robert J Amdur1, Jessica Kirwan1
1Department of Radiation Oncology, University of Florida, Gainesville, Florida.
Practical Radiation Oncology
|March 29, 2014
Summary
Radiation therapy effectively manages optic nerve sheath meningioma (ONSM), preventing tumor growth and vision loss in most patients. This treatment offers excellent local control and preserves useful vision for the majority of individuals with ONSM.
Area of Science:
- Neuro-oncology
- Radiation Oncology
- Ophthalmology
Background:
- Optic nerve sheath meningioma (ONSM) is an uncommon tumor.
- Management requires understanding radiation therapy's role.
- This study reviews institutional experience to guide oncologists.
Purpose of the Study:
- To outline essential concepts for managing ONSM patients with radiation therapy.
- To present institutional data on ONSM treatment outcomes.
- To establish radiation therapy's role in treating this rare tumor.
Main Methods:
- Retrospective review of 15 patients treated for ONSM between 1990-2006.
- Median follow-up of 12 years (minimum 5 years).
- Median radiation dose of 50.4 Gy at 1.8 Gy per fraction.
Main Results:
- 100% local control and relapse-free survival observed.
- No tumor progression in any patient.
- Vision remained stable or improved in 87% of patients; 86% retained useful vision.
Conclusions:
- Radiation therapy at 50.4 Gy prevents ONSM progression.
- This dose regimen is effective in preserving vision.
- Radiation therapy is a safe and effective treatment for ONSM.
