Segmented filamentous bacteria: commensal microbes with potential effects on research
Aaron C Ericsson1, Catherine E Hagan2, Daniel J Davis2
1Mutant Mouse Regional Resource Center (MMRRC), Rat Resource and Research Center (RRRC), Department of Veterinary Pathobiology, University of Missouri, Columbia, Missouri, USA. ericssona@missouri.edu.
Comparative Medicine
|March 29, 2014
Summary
Segmented filamentous bacteria (SFB) impact rodent immune development and disease models. Understanding these commensal bacteria is crucial for reliable research outcomes.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- Segmented filamentous bacteria (SFB) are commensal microbes found in rodent ilea.
- SFB were previously considered harmless but are now known to influence host immunity.
- SFB are difficult to culture in vitro, limiting previous study.
Purpose of the Study:
- To review the biology of SFB.
- To discuss the immunologic and physiologic effects of SFB colonization.
- To highlight SFB's impact on rodent models of disease and host-microbe interactions.
Main Methods:
- Literature review of SFB biology and effects.
- Analysis of SFB's influence on immune system development.
- Discussion of SFB's role in disease models.
Main Results:
- SFB significantly affect the development of the rodent immune system.
- SFB colonization alters the phenotype of rodent models for various diseases.
- SFB represent a critical intercurrent variable in rodent research.
Conclusions:
- SFB are key players in host-microbe interactions, influencing research outcomes.
- Further research into uncultured commensal microbes is needed.
- Characterizing host-microbe interactions is vital for the integrity of animal research.
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