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Occupational dermatoses from colour developing agents. Clinical and histopathological observations
1Division of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.
Acta Dermato-Venereologica
|January 1, 1988
Summary
Occupational exposure to color developing agents, like CD-2 and CD-3, can cause allergic contact dermatitis and lichenoid lesions. Most patients developed contact allergy, and many had to change jobs due to the skin disease.
Area of Science:
- Dermatology
- Occupational Health
- Toxicology
Background:
- p-phenylenediamine derivatives, such as CD-2 and CD-3, are known occupational sensitizers.
- Exposure can lead to lichenoid lesions and allergic contact dermatitis.
Purpose of the Study:
- To describe the clinical presentation, course, and patch test results of 24 patients with occupational skin disease from color developing agents.
- To investigate the histopathological findings of induced lesions and patch test reactions.
Main Methods:
- Clinical assessment of 24 patients with suspected occupational skin disease.
- Patch testing with color developing agents.
- Histopathological examination of skin biopsies from lesions and/or patch test sites in 14 patients.
Main Results:
- Allergic contact dermatitis and lichenoid lesions were observed.
- Contact allergy to color developing agents was confirmed in 23 out of 24 patients.
- Skin lesions resolved upon cessation of exposure; 16 patients required job changes.
- Histopathology of lesions showed lichen planus or lichen planus-like changes, while patch test reactions revealed dermatitis.
Conclusions:
- Color developing agents are significant occupational allergens causing dermatitis and lichenoid lesions.
- Occupational contact allergy to these agents necessitates cessation of exposure for resolution.
- Clinical and histopathological findings highlight lichen planus-like dermatoses as a common outcome.