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Clonidine in the treatment of mixed bipolar disorder
V Kontaxakis1, M Markianos, M Markidis
1Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
Acta Psychiatrica Scandinavica
|January 1, 1989
Abstract:
In a mixed bipolar disorder patient, DST-positive, treated with neuroleptics and antidepressants, the addition of clonidine (up to 0.6 mg/day) caused a rapid improvement in his psychopathology, without any significant side effects. The concentrations of the metabolites of noradrenaline, dopamine, and serotonin (MHPG, HVA, and 5-HIAA), the hormone prolactin and the activity of dopamine-beta-hydroxylase estimated in plasma during the clonidine trial are also reported.