Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intermediate filaments. Efficacy in surgical pathologic diagnosis.

R B Nagle1

  • 1Department of Pathology, University of Arizona, Tucson 85724.

American Journal of Clinical Pathology
|April 1, 1989
PubMed
Summary

Antibodies targeting intermediate filament proteins are crucial in surgical pathology for identifying cell types in tumors. Understanding their lineage-specific expression aids in accurate cancer diagnosis and classification.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in characteristics of men with localised prostate cancer who demonstrate low, intermediate or high prostate-specific antigen velocity.

Internal medicine journal·2011
Same author

Dose-dependent effects of selenized yeast on total selenium levels in prostatic tissue of men with prostate cancer.

Nutrition and cancer·2010
Same author

Nephrotoxicity and uptake of 1-benzyl quinolinium in precision-cut rabbit renal cortical slices.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Effects of acute and chronic arsenic exposure of human-derived keratinocytes in an In Vitro human skin equivalent system: a novel model of human arsenicism.

Toxicology in vitro : an international journal published in association with BIBRA·2010
Same author

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer.

British journal of cancer·2007
Same author

Site-specific positive margins at radical prostatectomy: assessing cancer-control benefits of wide excision of the neurovascular bundle on a side with cancer on biopsy.

BJU international·2003

Area of Science:

  • Cell Biology
  • Pathology
  • Immunohistochemistry

Background:

  • Intermediate filament proteins are key cytoskeletal components.
  • Their expression patterns are cell lineage-specific.
  • These patterns are maintained in neoplasms, aiding in diagnosis.

Purpose of the Study:

  • To review the discovery, embryology, and structure of intermediate filament proteins.
  • To discuss the applications of specific antibodies in surgical pathology.
  • To provide guidance on the selection and use of these antibodies.

Main Methods:

  • Review of historical literature on intermediate filament proteins.
  • Analysis of embryological development and protein structure.
  • Discussion of immunohistochemical techniques and antibody applications.

Main Results:

  • Intermediate filament proteins exhibit conserved, lineage-specific expression.
  • Antibodies to these proteins are valuable diagnostic tools in pathology.
  • Neoplasms often retain these characteristic expression patterns.

Conclusions:

  • Antibodies to intermediate filament proteins are indispensable in modern surgical pathology.
  • Knowledge of protein expression aids in differentiating tumors and determining origin.
  • Careful selection and use of antibodies are essential for reliable diagnostic outcomes.

Related Experiment Videos