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Updated: May 1, 2026
Identification and Quantification of Deranged Metabolites in Critically Ill Patients Using NMR-Based Metabolomics
Published on: November 29, 2024
Metabolomics in hypertension
Sonja B Nikolic1, James E Sharman, Murray J Adams
1aMenzies Research Institute Tasmania, University of Tasmania, Hobart bSchool of Human Life Sciences, University of Tasmania, Launceston, Australia cCentre of Human & Aerospace Physiological Sciences, King's College London, London, UK.
Insights
Metabolomics offers a powerful approach to understand the complex causes of hypertension, a common condition. This research explores how analyzing metabolic profiles can reveal new insights into hypertension development and treatment.
Area of Science:
- Cardiovascular Research
- Metabolomics
- Genomics
Background:
- Hypertension is a widespread chronic condition and a primary risk factor for cardiovascular disease.
- The complex, multifactorial nature of hypertension often obscures its underlying causes.
- Metabolomics provides a novel lens to examine metabolic changes linked to diseases.
Purpose of the Study:
- To review the application of metabolomics in understanding hypertension.
- To explore the potential of metabolomics in identifying hypertension biomarkers and mechanisms.
- To discuss future directions for metabolomics research in hypertension.
Main Methods:
- Review of analytical techniques and pre-analytical steps in metabolomics studies.
- Examination of study designs employed in metabolomics research for hypertension.
- Synthesis of current literature on metabolomics in cardiovascular disease research.
Main Results:
- Metabolomics is increasingly utilized to characterize cardiovascular disease risk factors, including hypertension.
- The field shows significant promise for uncovering the complex mechanisms underlying hypertension.
- Emerging evidence highlights metabolomics' role in gaining mechanistic insights into hypertension development.
Conclusions:
- Metabolomics is a valuable tool for dissecting the heterogeneity of hypertension.
- Further research using metabolomics can identify novel biomarkers and therapeutic targets for hypertension.
- This approach is crucial for advancing our understanding of cardiovascular health and disease.
Abstract:
Hypertension is the most prevalent chronic medical condition and a major risk factor for cardiovascular morbidity and mortality. In the majority of hypertensive cases, the underlying cause of hypertension cannot be easily identified because of the heterogeneous, polygenic and multi-factorial nature of hypertension. Metabolomics is a relatively new field of research that has been used to evaluate metabolic perturbations associated with disease, identify disease biomarkers and to both assess and predict drug safety and efficacy. Metabolomics has been increasingly used to characterize risk factors for cardiovascular disease, including hypertension, and it appears to have significant potential for uncovering mechanisms of this complex disease. This review details the analytical techniques, pre-analytical steps and study designs used in metabolomics studies, as well as the emerging role for metabolomics in gaining mechanistic insights into the development of hypertension. Suggestions as to the future direction for metabolomics research in the field of hypertension are also proposed.
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