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Related Experiment Videos

C-reactive protein and bacterial meningitis.

L E Cuevas1, C A Hart, M Molyneux

  • 1School of Tropical Medicine, Liverpool, U.K.

Annals of Tropical Paediatrics
|December 1, 1988
PubMed
Summary
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Cerebrospinal fluid C-reactive protein (CSF CRP) shows potential for diagnosing bacterial meningitis. However, its utility is limited in regions with high rates of tuberculous meningitis and malaria.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Clinical Chemistry

Background:

  • Bacterial meningitis is a critical condition requiring rapid diagnosis.
  • Distinguishing bacterial meningitis from other neurological infections like tuberculous meningitis and severe malaria can be challenging.
  • C-reactive protein (CRP) is an inflammatory marker that can be elevated in infections.

Purpose of the Study:

  • To evaluate the diagnostic value of cerebrospinal fluid C-reactive protein (CSF CRP) in differentiating bacterial meningitis from other central nervous system infections.
  • To determine the sensitivity and specificity of CSF CRP at a threshold of 1 mg/l.

Main Methods:

  • Prospective study of 54 patients.
  • Analysis of CSF CRP levels in patients with bacterial meningitis, tuberculous meningitis, severe malaria with convulsions, and non-infectious neurological conditions.

Related Experiment Videos

  • Comparison of CSF CRP values against confirmed diagnoses.

    • Main Results:

    • CSF CRP above 1 mg/l was found in 82% of bacterial meningitis patients.
    • Specificity was 73% at the 1 mg/l threshold.
    • Elevated CSF CRP was also observed in tuberculous meningitis and some severe malaria cases, limiting its discriminatory power.

    Conclusions:

    • CSF CRP is a sensitive marker for bacterial meningitis but lacks specificity in areas where malaria and tuberculous meningitis are prevalent.
    • CSF CRP alone is not a reliable discriminatory test for meningitis in endemic regions co-endemic for malaria and TB.