Related Experiment Videos
1,4-naphthoquinone-2-sulfonic acid derivatives coupled to dextran as carriers for interferon
E Piasecki1, D Charytonowicz, M Konieczny
1Laboratory of Tumor Virology, Polish Academy of Sciences, Wrocław.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1988
Abstract:
Three derivatives of 1,4-naphthoquinone-2-sulfonic acid possessing the fragments of Cibacron Blue (CB) were synthesized and bound to Dextran T 2000 by ether binding. Polymers IVD, VD and VID were incubated with interferon (IFN) to obtain complexes: carrier-IFN. It was found that polymer VID has weaker affinity to mouse IFN-beta/alpha and to human IFN-beta than Blue Dextran. The polymers IVD and VD had no affinity to the interferon.