Viral OTU deubiquitinases: a structural and functional comparison.
Ben A Bailey-Elkin1, Puck B van Kasteren2, Eric J Snijder2
1Department of Microbiology, University of Manitoba, Winnipeg, Canada.
Plos Pathogens
|March 29, 2014
Summary
Diverse RNA viruses utilize proteases structurally similar to ovarian tumor (OTU) deubiquitinases (DUBs). This comparison highlights shared features and unique differences, prompting origin speculation for these viral OTU DUBs.
Area of Science:
- Virology
- Structural Biology
- Enzymology
Background:
- Recent studies reveal diverse RNA viruses encode proteases.
- These viral proteases exhibit structural similarity to ovarian tumor (OTU) superfamily deubiquitinases (DUBs).
- Rapid succession of reports hindered recognition of shared viral enzyme features.
Purpose of the Study:
- To provide a structural and functional comparison of virus-encoded OTU DUBs.
- To discuss the shared features among these viral enzymes.
- To explore the origins of these enzymes based on structural and functional data.
Main Methods:
- Structural comparison of viral proteases and human OTU DUBs.
- Functional analysis of substrate specificity.
- Comparative analysis of evolutionary origins.
Main Results:
- Virus-encoded OTU DUBs share structural similarities with human OTU DUBs.
- These viral enzymes exhibit conserved substrate specificity.
- Notable differences exist between viral OTU DUBs, suggesting distinct evolutionary paths.
Conclusions:
- Virus-encoded proteases belong to the OTU DUB superfamily.
- Shared structural and functional traits suggest a common ancestry or convergent evolution.
- Differences in viral OTU DUBs warrant further investigation into their origins.
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