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Updated: May 1, 2026
Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
Published on: December 30, 2025
Tryptophan as the fingerprint for distinguishing aggressiveness among breast cancer cell lines using native
Lin Zhang1, Yang Pu2, Jianpeng Xue3
1City College of the City University of New York, Department of Biomedical Engineering, 160 Convent Avenue, New York, New York 10031.
Abstract:
Tryptophan is investigated as the key native marker in cells to determine the level of metastasis competence in breast cell lines using native fluorescence spectroscopy. The ratio of fluorescence intensity at 340 nm to intensity at 460 nm is associated with aggressiveness of the cancer cells. We found that the fluorescence of aggressive breast cancer cell has a much higher contribution from tryptophan compared with that from the normal cells and nonaggressive breast cancer cell.
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