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Does post-infectious olfactory loss affect mood more severely than chronic sinusitis with olfactory loss?
Yong G Jung1, Jun-Seok Lee, Gi C Park
1Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Korea.
The Laryngoscope
|March 29, 2014
Summary
Olfactory loss after viral upper respiratory infection (URI) more severely impacts mood than chronic sinusitis. This mood impact in URI patients was independent of age, sex, or olfactory function severity.
Area of Science:
- Otolaryngology
- Neuroscience
- Psychiatry
Background:
- Olfactory dysfunction is a common symptom of upper respiratory infections (URIs) and chronic sinusitis.
- The psychological impact, particularly on depression, may differ between these conditions.
- Previous research has not directly compared the depression index in patients with post-URI olfactory loss versus chronic sinusitis-related olfactory loss.
Purpose of the Study:
- To compare the depression index in patients with olfactory loss following a viral URI versus those with olfactory loss due to chronic sinusitis.
- To investigate the correlation between olfactory function (TDI score) and depression (BDI score) in both groups.
- To determine if demographic factors (age, sex) influence the depression index in relation to olfactory loss.
Main Methods:
- A prospective study involving 50 participants, divided into two groups: 25 with post-URI olfactory loss and 25 with chronic sinusitis and olfactory loss.
- Control group participants were matched for age, sex, and olfactory loss severity (TDI score).
- Beck Depression Inventory (BDI) scores were compared between groups, and correlations between TDI and BDI scores were analyzed.
Main Results:
- The mean BDI score was significantly higher in the post-URI olfactory loss group (14.52 ± 6.59) compared to the chronic sinusitis group (9.32 ± 5.23).
- In the post-URI group, age, sex, and TDI score did not significantly affect BDI scores.
- In the chronic sinusitis group, BDI scores were inversely correlated with TDI scores, and female subjects reported higher BDI scores than males.
Conclusions:
- Post-URI olfactory loss leads to a more severe impact on mood and depression compared to chronic sinusitis with similar olfactory deficits.
- The severity of mood impairment in post-URI olfactory loss is not influenced by age, sex, or the degree of olfactory loss.
- These findings highlight the distinct psychological sequelae of different causes of olfactory dysfunction.
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