Creation of neovascularised free flaps using vein grafts as pedicles: a preliminary report on experimental models

In a rat model, based on the concept of neovascularisation, an interposition vein-grafted arterial-venous fistula pedicle was used to create neovascularised skin, muscle, and bone free flaps. The important feature of these flaps is that neovascularisation of the selected flap tissues was achieved with a vein graft, unlike earlier studies using local arteries and veins as pedicles. Within a few weeks sufficient neovascularisation developed to support free transfer of the flaps based on the implanted vein graft pedicle. After successful transfer these flaps were harvested for histological examination. The implications of the clinical application of this technique are discussed.