Related Experiment Video For ADC
Updated: May 1, 2026
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
Published on: December 15, 2014
Apparent diffusion coefficient (ADC) measurement in endometrial carcinoma: effect of region of interest methods on
Chie Inoue1, Shinya Fujii, Sachi Kaneda
1Division of Radiology, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, Yonago, Japan.
Purpose:
To investigate the influence of different-shaped regions of interest (ROIs) on tumor apparent diffusion coefficient (ADC) measurements and interobserver variability in endometrial carcinoma.
Materials And Methods:
Sixty-nine patients (age range, 32-92 years; mean, 61 years) were evaluated in this retrospective study. Patients had undergone magnetic resonance (MR) examinations including diffusion-weighted imaging (DWI) using a 3.0-T MR system. Two readers measured tumor ADCs using four ROI methods: freehand ROI; square ROI; round ROI; and five small, round ROIs. Minimum and mean ADCs were obtained. The interclass correlation coefficient (ICC) was statistically analyzed to assess measurement reliability. Repeated-measures analysis of variance was used for comparisons of ADCs measured with each ROI method.
Results:
ICCs were 0.93 (minimum ADC) / 0.93 (mean ADC) for freehand ROIs, 0.94/0.95 for square ROIs, 0.94/0.95 for round ROIs, and 0.95/0.96 for five small, round ROIs. All ROI methods indicated excellent correlations. Each minimum ADC was significantly different except between square ROI and round ROI (P < 0.001). Mean ADCs showed significant differences only between freehand ROI and the other ROI methods (P < 0.001).
Conclusion:
ROI shape has no marked influence on ICC in endometrial carcinoma. Compared with minimum ADCs, mean ADCs are suggested to provide more stable results regardless of the ROI method.
