Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Automated Microbial Diagnostics01:24

Automated Microbial Diagnostics

77
Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...
77
Statistical Software for Data Analysis and Clinical Trials01:12

Statistical Software for Data Analysis and Clinical Trials

1.7K
Statistical software is pivotal in data analysis and clinical trials by providing tools to analyze data, draw conclusions, and make predictions. These software packages range from simple data management applications to complex analytical platforms, supporting various statistical tests, models, and simulation techniques. Their significance lies in their ability to handle vast amounts of data with precision and efficiency, enabling researchers to validate hypotheses, identify trends, and make...
1.7K
Enzyme-Linked Immunosorbent Assay01:33

Enzyme-Linked Immunosorbent Assay

14.1K
In 1971, Peter Perlman and Eva Engvall developed an Enzyme-linked immunosorbent assay (ELISA or EIA). ELISA differs from western blot in that the assays are conducted in microtiter plates or in vivo rather than on an absorbent membrane.
There are many different types of ELISAs, but they all involve an antibody molecule whose constant region binds an enzyme, leaving the variable region free to bind its specific antigen.  Enzyme-substrate reaction allows the antigen to be visualized or...
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re: Liu et al., "On the reported methodology in published TriNetX-based studies: an analysis of impossible index event designs".

European journal of epidemiology·2026
Same author

TriNetX Dataworks-USA: Overview of a Multi-Purpose, De-Identified, Federated Electronic Health Record Real-World Data and Analytics Network and Comparison to the US Census.

Pharmacoepidemiology and drug safety·2025
Same author

A rapid cycle analytics framework for vaccine safety surveillance within a real-world data network: Experience with enhanced surveillance of the Janssen COVID-19 vaccine.

Vaccine·2025
Same author

Quantitative Benefit-Risk Assessment of Vaccination Against COVID-19: A Systematic Review.

Pharmacoepidemiology and drug safety·2025
Same author

Advancing Principled Pharmacoepidemiologic Research to Support Regulatory and Healthcare Decision Making: The Era of Real-World Evidence.

Clinical pharmacology and therapeutics·2025
Same author

New Diagnoses of Juvenile Idiopathic Arthritis Early in the COVID-19 Pandemic: Analysis of a Large United States Commercial Insurance Database.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2024

Related Experiment Video

Updated: May 1, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.9K

Electronic clinical laboratory test results data tables: lessons from Mini-Sentinel.

Marsha A Raebel1, Kevin Haynes, Tiffany S Woodworth

  • 1Institute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA; University of Colorado Skaggs, School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA.

Pharmacoepidemiology and Drug Safety
|March 29, 2014
PubMed
Summary

Developing a common data model for electronic clinical data, specifically the Mini-Sentinel Distributed Database laboratory results table (LRT), faced unique challenges. Harmonization efforts and systematic approaches are crucial for managing disparate clinical laboratory data.

Keywords:
administrative databaseclinical databasedistributed data networkelectronic laboratory databaseslaboratory test resultspharmacoepidemiologypost-marketing evaluationsafety surveillance

More Related Videos

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

840
TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.3K

Related Experiment Videos

Last Updated: May 1, 2026

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management
05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

1.9K
Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow
08:58

Efficient Sampling of Genetically Encoded Biosensor Design Space Enabled with a Design of Experiments and Automation Workflow

Published on: October 17, 2025

840
TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients
09:00

TBase - an Integrated Electronic Health Record and Research Database for Kidney Transplant Recipients

Published on: April 13, 2021

5.3K

Area of Science:

  • Health Informatics
  • Clinical Data Management
  • Biostatistics

Background:

  • Electronic clinical data present unique challenges for common data model development compared to administrative data.
  • Standardizing laboratory results from diverse sources is essential for large-scale health research.

Purpose of the Study:

  • To describe the design, implementation, and application of the Mini-Sentinel Distributed Database laboratory results table (LRT).
  • To address the complexities of integrating electronic clinical data into a unified data model.

Main Methods:

  • Developed the LRT and guided data partners (DPs) in populating it from electronic health records and laboratory systems.
  • Utilized Logical Observation Identifiers, Names, and Codes (LOINC®) for results reporting standards.
  • Employed data checks and iterative characterization/harmonization for data evaluation.

Main Results:

  • The LRT includes key variables such as test name, specimen source, LOINC codes, and patient identifiers.
  • Twelve DPs contributed outpatient and inpatient laboratory test results, totaling over 385 million results by September 2013.
  • Variations in LOINC availability and data quality issues were identified and addressed.

Conclusions:

  • Integrating disparate clinical laboratory data requires a systematic approach to overcome non-standardized coding and documentation.
  • Ongoing data harmonization, oversight, and management are vital for maintaining the validity and utility of the LRT.
  • The LRT demonstrates a method for consolidating clinical laboratory results for distributed research networks.