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Updated: May 1, 2026
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
Published on: June 7, 2015
Accelerated radiotherapy for T1 to T2 glottic cancer
Atsushi Motegi1, Mitsuhiko Kawashima, Satoko Arahira
1Division of Radiation Oncology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
Background:
Accelerated fractionation radiotherapy (RT) was administered in an attempt to improve the local control rates in patients with T1/T2 N0 glottic cancer.
Methods:
Medical charts of 148 consecutive patients who had undergone RT using 2.4 Gray (Gy) once-daily fractionation between July 1999 and April 2007 were reviewed.
Results:
Of 104 patients with T1 disease treated by RT, 82 received 60 Gy/25 fractions, and the remaining 22 with large tumor volumes and/or slow response to RT received 64.8 Gy/27 fractions. All 44 patients with T2 disease received 64.8 Gy/27 fractions. The 5-year local control and overall survival (OS) rates were 93% and 96%, respectively, in patients with T1 disease, and 77% and 91%, respectively, in patients with T2 disease. No severe acute toxicities were observed, although 2 patients (1%) developed severe late toxicity.
Conclusion:
Accelerated RT for early glottic cancer is feasible, with encouraging local control rates.
