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Electrospun Fibrous Scaffolds of Polyglycerol-dodecanedioate for Engineering Neural Tissues From Mouse Embryonic Stem Cells
Published on: June 18, 2014
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Nano/microfibrous polymeric constructs loaded with bioactive agents and designed for tissue engineering applications:
Dario Puppi1, Xuanmiao Zhang, Likai Yang
1Department of Chemistry and Industrial Chemistry, Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), University of Pisa, 56010, San Piero a Grado (Pi), Italy.
Summary
This review covers advanced methods for creating nano/microfibrous scaffolds for tissue engineering. These biomaterials, enhanced with bioactive agents, promote tissue regeneration and therapeutic effects.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Nano/microfibrous polymeric constructs offer high porosity and surface area, ideal for tissue engineering applications.
- Electrospinning and other fabrication techniques create scaffolds mimicking the extracellular matrix, promoting cell attachment and activity.
- Existing methods enable the creation of 3D scaffolds with micropores for effective cell migration.
Purpose of the Study:
- To review current advances in manufacturing nano/microfibrous polymeric constructs for tissue engineering scaffolds.
- To summarize methods for biofunctionalizing these scaffolds with various bioactive agents.
- To highlight the potential for promoting tissue regeneration and therapeutic effects.
Main Methods:
- Fabrication techniques including electrospinning, wet-spinning, and additive manufacturing for scaffold creation.
- Biofunctionalization strategies such as direct blending, coaxial electrospinning, and microparticle incorporation.
- Combination of different processing and loading techniques for complex, multiscale scaffold structures.
Main Results:
- Development of scaffolds with controlled porosity, surface area, and 3D architecture.
- Tailored release kinetics of bioactive agents (small molecules, proteins, cells) from scaffolds.
- Creation of biomimetic scaffolds with hierarchical architecture and sophisticated release profiles.
Conclusions:
- Advanced manufacturing and biofunctionalization techniques are crucial for developing effective tissue engineering scaffolds.
- Combinatorial approaches enable the design of sophisticated scaffolds for enhanced tissue regeneration.
- These biomimetic constructs hold significant promise for future therapeutic applications.
