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A Power-Efficient Wireless System With Adaptive Supply Control for Deep Brain Stimulation.

Hyung-Min Lee1, Hangue Park1, Maysam Ghovanloo1

  • 1School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA 30308 USA.

IEEE Journal of Solid-State Circuits
|March 29, 2014
PubMed
Summary

This study presents a power-efficient wireless system for deep brain stimulation (DBS). It features an adaptive rectifier and closed-loop control for improved efficiency and safety in neural stimulation.

Keywords:
Active charge balancingadaptive rectifierclosed-loop supply controlhead-mounted deep brain stimulationimplantable medical devicesinductive power transfer

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Area of Science:

  • Biomedical Engineering
  • Electrical Engineering
  • Neuroscience

Background:

  • Deep brain stimulation (DBS) systems require efficient power delivery.
  • Wireless power transfer is desirable for implantable devices like DBS.
  • Existing systems face challenges in power efficiency and precise stimulation control.

Purpose of the Study:

  • To develop a power-efficient wireless stimulating system for head-mounted DBS.
  • To enhance stimulation efficiency and safety through adaptive control.
  • To demonstrate a compact, integrated wireless DBS prototype.

Main Methods:

  • Designed an adaptive rectifier with phase control feedback for efficient AC-DC conversion.
  • Implemented a current-controlled stimulator with closed-loop supply control and voltage readout.
  • Utilized closed-loop active charge balancing for safety.
  • Fabricated a 4-channel wireless stimulating system prototype using 0.5-μm CMOS technology.

Main Results:

  • Achieved high AC-DC power conversion efficiency (PCE) of 72-87% with the adaptive rectifier.
  • Adaptive supply control improved stimulation efficiency by up to 30% compared to fixed voltage.
  • Demonstrated adjustable DC output voltage (2.5-4.6 V) from a constant AC input.
  • Verified the prototype's functionality *in vitro*.

Conclusions:

  • The developed wireless stimulating system offers significant power efficiency improvements for DBS.
  • Adaptive control strategies enhance stimulation efficacy and ensure safety.
  • The compact CMOS prototype demonstrates the feasibility of wireless, efficient DBS.