Related Experiment Video
Updated: May 1, 2026
07:16
Human Vastus Lateralis Skeletal Muscle Biopsy Using the Weil-Blakesley Conchotome
Published on: March 4, 2016
16.5K
Structural alterations of skeletal muscle in copd
Sunita Mathur1, Dina Brooks1, Celso R F Carvalho2
1Department of Physical Therapy, University of Toronto Toronto, ON, Canada.
Frontiers in Physiology
|March 29, 2014
Summary
Muscle wasting and structural changes are prevalent in chronic obstructive pulmonary disease (COPD), impacting physical function and survival. Understanding these cellular modifications is key for developing effective rehabilitation strategies.
Area of Science:
- Pulmonary Medicine
- Muscle Physiology
- Cellular Biology
Background:
- Chronic obstructive pulmonary disease (COPD) involves a systemic inflammatory response.
- Peripheral muscle dysfunction is a known complication of COPD, stemming from complex systemic and local factors.
Purpose of the Study:
- To review muscle wasting in COPD patients.
- To describe associated structural changes, regenerative capacity, and potential mechanisms of muscle wasting.
- To explore the relationship between structural changes and impaired muscle function/mobility in COPD.
Main Methods:
- Narrative review of existing literature.
- Analysis of cellular and structural modifications in peripheral muscles of COPD patients.
- Examination of muscle regenerative capacity and potential contributing mechanisms.
Main Results:
- 30-40% of COPD patients exhibit muscle mass depletion, a predictor of mortality.
- Structural changes include reduced type-I fibers, oxidative capacity, and mitochondrial density.
- Impaired regeneration is indicated by fewer central nuclei and shorter telomere length.
Conclusions:
- Cellular modifications in peripheral muscles are evident in COPD and linked to impaired function.
- Further research is needed for rehabilitation strategies targeting muscle wasting and function maximization.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
5.0K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
5.0K
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
40
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
40
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
48
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
48
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
4.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
4.0K
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
30
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet...
30
01:20COPD: Pathogenesis and Clinical Features
2.1K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
2.1K