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Updated: May 1, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

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Cardiovascular Risk Factors and Chronic Kidney Disease-FGF23: A Key Molecule in the Cardiovascular Disease

Rika Jimbo1, Tatsuo Shimosawa2

  • 1Department of Internal Medicine, Odaira-Memorial Tokyo Hitachi Hospital, 3-5-7 Yushima, Bunkyo-ku, Tokyo, Japan.

International Journal of Hypertension
|March 29, 2014
PubMed

Insights

Fibroblast growth factor 23 (FGF23) is linked to cardiovascular risks in chronic kidney disease (CKD). Targeting FGF23 may offer new therapies to improve patient outcomes.

Area of Science:

  • Nephrology
  • Cardiology
  • Endocrinology

Background:

  • Chronic kidney disease (CKD) patients face elevated mortality, primarily from cardiovascular disease.
  • CKD is associated with mineral and bone disorder (CKD-MBD), exacerbating cardiovascular risk.
  • Fibroblast growth factor 23 (FGF23) discovery revealed complex endocrine interactions in CKD-MBD.

Purpose of the Study:

  • To explore the association between FGF23 and cardiovascular complications in CKD.
  • To investigate the role of the FGF23-Klotho axis in vascular health.
  • To evaluate FGF23 as a potential therapeutic target for CKD patients.

Main Methods:

  • Review of clinical studies on FGF23 and cardiovascular outcomes.
  • Analysis of translational research on the FGF23-Klotho axis in vasculature.
  • Examination of FGF23's causative role in cardiovascular disease.

Main Results:

  • FGF23 is associated with increased cardiovascular risks, left ventricular hypertrophy, and vascular calcification in CKD.
  • The FGF23-Klotho axis exists in the vasculature.
  • FGF23 has a causative effect on cardiovascular disease.

Conclusions:

  • FGF23 plays a significant role in cardiovascular complications of CKD.
  • The FGF23-Klotho axis is implicated in vascular pathology.
  • FGF23 represents a promising therapeutic target for improving cardiovascular outcomes in CKD.

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