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A comparison of benflurone effects after intravenous infusion or oral administration. A study on laboratory rats
1Laboratory of Haematology, Research Institute for Pharmacy and Biochemistry, Pardubice, CSSR.
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1988
Abstract:
The effects of oral administration and intravenous infusion of benflurone were compared using the single dose of 100 mg/kg b.w. Oral administration of benflurone induced more moderate changes in both white and red blood picture than the equal dose of orally administered cyclophosphamide. In contrast to oral benflurone administration, intravenous benflurone induced deep anaemia, deep reticulocytopenia, transient neutrophilia and slight decrease in small lymphocyte counts. The recovery from intravenous benfluorone effects was rapid.