Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

160
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
160
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists01:23

Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists

613
Prostacyclin receptor agonists are a class of therapeutic agents integral to managing pulmonary arterial hypertension (PAH). These drugs operate by mimicking the action of prostaglandin I2, or PGI2, a naturally occurring compound in the body.
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
613

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NO-PDT and chemotherapy: spatiotemporal control to achieve therapeutic synergy.

Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology·2026
Same author

Development and clinical evaluation of a nanoemulsion for buccal delivery of cannabis extract in refractory chronic pain.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

A Molecular Hybrid for Double Stepwise Nitric Oxide Photorelease with Double Fluorescence Readout in Living Cells.

Chemical & biomedical imaging·2026
Same author

PEG-lipid structure controls in vitro PEG shedding, surface remodeling, and timing of lipid nanoparticle-mediated silencing.

Journal of colloid and interface science·2026
Same author

Lipid@polymer hybrid nanoparticles for efficient siRNA transport across the lung barriers: Mechanistic insights into the role of Ionizable lipids.

Journal of colloid and interface science·2026
Same author

Poly-L-Lysine Doped FmocFF Nanogels as Delivery Platforms for siRNA.

ACS applied bio materials·2026

Related Experiment Video

Updated: May 1, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.8K

PEGylated polyester-based nanoncologicals.

Claudia Conte, Ivana d'Angelo, Agnese Miro

  • 1Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli - Italy. quaglia@unina.it.

Current Topics in Medicinal Chemistry
|April 1, 2014
PubMed
Summary

This review covers PEGylated polyester nanocarriers for cancer drug delivery, focusing on intravenous, oral, and pulmonary administration routes. These nanocarriers are advancing through preclinical and clinical trials, with some already on the market.

More Related Videos

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

15.6K
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

10.6K

Related Experiment Videos

Last Updated: May 1, 2026

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.8K
Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

15.6K
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
09:01

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Published on: September 27, 2013

10.6K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Polyethylene glycol (PEG)-conjugated polyesters are emerging as key materials for nanomedicine.
  • Numerous PEGylated polyester nanocarriers have been developed for cancer therapy.
  • Some of these nanocarriers are currently in clinical trials or have reached the market.

Purpose of the Study:

  • To review the main features of PEGylated polyesters and their nanocarriers.
  • To discuss PEGylated nanocarriers for intravenous, oral, and pulmonary drug delivery.
  • To explore technological aspects and therapeutic implications of these nanocarriers.

Main Methods:

  • Literature review of PEGylated polyester-based nanoncologicals.
  • Analysis of design principles for intravenous administration.
  • Examination of nanocarriers in preclinical/clinical investigation and market.

Main Results:

  • PEGylated nanocarriers are extensively studied for intravenous delivery, with established design rules.
  • Technological advancements and therapeutic potentials of marketed/investigational nanocarriers are detailed.
  • Emerging applications for oral and pulmonary delivery are considered.

Conclusions:

  • PEGylated polyester nanocarriers represent a significant advancement in cancer drug delivery.
  • Intravenous administration is the most explored route, with promising clinical translation.
  • Future research directions include optimizing oral and pulmonary delivery systems for enhanced anticancer efficacy.