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Serum uric acid can predict higher C-reactive protein levels in apparently healthy men
Fernanda de Carvalho Vidigal1, Lina Enriqueta Frandsen Paez de Lima Rosado2, Gilberto Paixão Rosado2
1Department of Nutrition and Health. Universidade Federal de Viçosa. Minas Gerais. Brazil.. fcvidigal@gmail.com.
Insights
Uric acid effectively identifies high high-sensitivity C-reactive protein (hs-CRP) levels, while cholesterol ratios predict fibrinogen changes in healthy men, aiding cardiovascular disease prevention.
Area of Science:
- Biochemistry
- Cardiovascular Medicine
- Preventive Cardiology
Background:
- Epidemiological studies link coronary heart disease to emerging risk factors like fibrinogen and high-sensitivity C-reactive protein (hs-CRP).
- Identifying reliable biochemical markers is crucial for early cardiovascular risk assessment in apparently healthy individuals.
Purpose of the Study:
- To evaluate the discriminatory power of various biochemical indicators for changes in hs-CRP and fibrinogen levels.
- To assess the utility of these markers in identifying cardiovascular risk in adult men.
Main Methods:
- A cohort of 130 apparently healthy men (aged 20-59) was studied.
- Biochemical parameters including lipid profile, fasting glucose, uric acid, hs-CRP, and fibrinogen were measured.
- Calculated metrics included body mass index and cholesterol ratios (total cholesterol/HDL-c, LDL-c/HDL-c).
Main Results:
- Uric acid demonstrated the strongest correlation (r=0.325) and highest ROC area (0.704) for discriminating elevated hs-CRP levels (p<0.01).
- Total cholesterol/HDL-c and LDL-c/HDL-c ratios showed significant correlations (r=0.222, r=0.235) and ROC areas (0.624) for identifying higher fibrinogen levels (p<0.05).
Conclusions:
- Uric acid and cholesterol ratios are valuable biochemical markers for identifying changes in hs-CRP and fibrinogen, respectively.
- These markers can aid in clinical practice for establishing preventive strategies against cardiovascular disease in apparently healthy adult men.
Introduction:
Epidemiological studies have shown an association between coronary heart disease and emerging cardiovascular risk factors, such as, levels of fibrinogen and high-sensitivity C-reactive protein (hs-CRP).
Objectives:
To verify the ability of biochemical indicators in discriminating changes in the levels of hs-CRP and fibrinogen, in apparently healthy adult men.
Methods:
Were evaluated 130 apparently healthy men (20-59 years), having measurement of weight and height. Biochemical measurements (lipid profile, fasting glucose, uric acid, hs-CRP and fibrinogen) were performed. Body mass index, total cholesterol/HDL-c and LDL-c/HDL-c ratios were calculated. It was considered as the cutoff point for hs-CRP values ≥ 0.12 mg/dL and for fibrinogen the 50th percentile of the evaluated sample.
Results:
The uric acid showed the best correlation (r = 0.325) and the higher area under the ROC curve (0.704 ± 0.054), showing greater ability to discriminate higher levels of hs-CRP (p < 0.01). The total cholesterol/HDL-c ratio (r = 0.222) and the LDL-c/HDL-c ratio (r = 0.235) showed the best correlations and the higher areas under the ROC curves (0.624 ± 0.049 and 0.624 ± 0.049) in identify higher levels of fibrinogen (p < 0.05).
Conclusion:
The uric acid and the total cholesterol/HDL-c and the LDL-c/HDL-c ratios showed greater ability to identify changes in the levels of hs-CRP and fibrinogen, respectively. It was suggested the use of biochemical markers in the clinical practice, in order to establish preventive action for cardiovascular disease in apparently healthy adult men.
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