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Circular dichroism spectra of uridine derivatives: ChiraSac study
Tomoo Miyahara1, Hiroshi Nakatsuji, Takehiko Wada
1Quantum Chemistry Research Institute (QCRI), JST-CREST , Kyodai Katsura Venture Plaza, North Building 107, 1-36 Goryo-Oohara, Nishikyo-ku, Kyoto, 615-8245, Japan.
Abstract:
The experimental circular dichroism (CD) spectra of uridine and NH2-uridine that were different in the intensity and shape were studied in the light of the ChiraSac method. The theoretical CD spectra at several different conformations using the symmetry-adapted-cluster configuration-interaction (SAC-CI) theory largely depended on the conformational angle, but those of the anti-conformers and the Boltzmann average reproduced the experimentally obtained CD spectra of both uridine and NH2-uridine. The differences in the CD spectra between the two uridine derivatives were analyzed by using the angle θ between the electric transition dipole moment (ETDM) and the magnetic transition dipole moment (MTDM).
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