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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
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Innate lymphoid cells and asthma.

Sanhong Yu1, Hye Young Kim2, Ya-Jen Chang3

  • 1Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Mass.

The Journal of Allergy and Clinical Immunology
|April 1, 2014
PubMed
Summary
This summary is machine-generated.

Asthma has allergic and nonallergic forms. Innate lymphoid cells are key players in nonallergic asthma, producing cytokines like IL-5 and IL-13, and are crucial for understanding this complex disease.

Keywords:
Airway hyperreactivityallergyasthmainfluenzainnate lymphoid cellsnatural killer T cells

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Area of Science:

  • Immunology
  • Respiratory Medicine

Background:

  • Asthma is a heterogeneous respiratory disease with distinct allergic and nonallergic phenotypes.
  • Allergic asthma involves adaptive immunity and T-helper 2 (TH2) cytokines.
  • Nonallergic asthma phenotypes are linked to environmental factors and innate immunity.

Purpose of the Study:

  • To review recent data on innate lymphoid cells (ILCs).
  • To elucidate the role of ILCs in nonallergic asthma pathogenesis.
  • To highlight ILCs as critical components of innate immunity in asthma.

Main Methods:

  • Literature review of recent research on ILCs and asthma.
  • Analysis of studies focusing on innate immune pathways in nonallergic asthma.
  • Examination of cytokine production by ILCs, including IL-5 and IL-13.

Main Results:

  • Nonallergic asthma involves innate immune cells like macrophages, neutrophils, and ILCs.
  • ILCs are newly described cells implicated in innate immune responses.
  • ILCs produce key cytokines such as IL-5 and IL-13, relevant to asthma.

Conclusions:

  • Innate lymphoid cells play a significant role in nonallergic asthma.
  • Understanding ILCs is essential for differentiating and treating asthma phenotypes.
  • ILCs represent a critical focus for future asthma research and therapeutic strategies.