Related Experiment Video
Updated: May 1, 2026
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Relationship between plasma vascular endothelial growth factor and tumor necrosis factor-alpha and obstructive sleep
Jian Li1, Chuang Li1, Liping Chai1
1Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.
Insights
Plasma levels of vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) are elevated in children diagnosed with obstructive sleep apnea-hypopnea syndrome (OSAHS). These inflammatory markers show a significant increase in children with OSAHS compared to controls.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Immunology
Context:
- Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a prevalent condition in children.
- Inflammatory markers are implicated in the pathophysiology of various diseases.
- Understanding the role of specific biomarkers in pediatric OSAHS is crucial for diagnosis and management.
Purpose:
- To investigate the association between plasma levels of vascular endothelial growth factor (VEGF) and tumor necrosis factor-alpha (TNF-α) and the presence of OSAHS in children.
- To compare these biomarker levels in children with OSAHS, snoring alone, and healthy controls.
Summary:
- Plasma VEGF and TNF-α concentrations were significantly higher in children with OSAHS compared to those with snoring alone and healthy children.
- No significant differences were observed between children with snoring alone and healthy controls.
- No significant correlation was found between VEGF/TNF-α levels and polysomnographic parameters or BMI.
Impact:
- This study identifies VEGF and TNF-α as potential biomarkers for OSAHS in pediatric populations.
- Findings contribute to understanding the inflammatory mechanisms underlying pediatric OSAHS.
- May inform future diagnostic or therapeutic strategies targeting inflammation in pediatric sleep disorders.
Objective:
To investigate the relation of plasma vascular endothelial growth factor(VEGF) and tumor necrosis factor-α (TNF-α) with obstructive sleep apnea-hypopnea syndrome(OSAHS) in children.
Methods:
Eighty children were recruited from October 2008 to March 2009, including 60 children with snoring and 20 healthy children without snoring as control. Plasma VEGF or TNF-α concentration was measured by enzyme-linked immunosorbent assay (ELISA) respectively. Sixty children with snoring underwent an overnight polysomnography test their PSG data, including whole night mean saturation (MSaO2), lowest oxygen saturation (LSaO2), desaturation cumulate time/total sleep time (DCT/TST), oxygen desaturation index 3 (ODI3), apnea-hypopnea index (AHI), obstructive apnea index (OAI), were collected and analysed. SPSS 13.0 software was used to analyze the data.
Results:
The levels of plasma VEGF and TNF-α in children with OSAHS(540.45 pg/ml and 311.94 pg/ml) were higher than those in children with snoring alone (234.45 pg/ml and 97.55 pg/ml) or those in healthy children (259.80 pg/ml and 120.70 pg/ml), with statistically significant differences(HC value:14.176 and 15.571, P < 0.05, respectively), but with no statistical difference between children with snoring alone and healthy children (P > 0.05). The differences in plasma VEGF or TNF-α levels between children with moderate and severe hypoxemia and children with mild hypoxemia were not statistically significant (P > 0.05). Spearman rank correlation analysis showed no significant correlation between plasma level of VEGF or TNF-α and LSaO2, MSaO2, ODI3, DCT/TST, OAI, AHI or BMI (r values were <0.5, P > 0.05).
Conclusion:
Plasma levels of VEGF and TNF-α increase in children with OSAHS.
Related Concept Videos
01:24Regulation of Angiogenesis and Blood Supply
01:21Sleep Apnea
The condition is more prevalent among...
01:30Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...