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Related Experiment Video

Updated: May 1, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
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Is autoimmune thyroid dysfunction a risk factor for gestational diabetes?

Eider Pascual Corrales1, Patricia Andrada1, María Aubá2

  • 1Departamento de Endocrinología y Nutrición, Clínica Universidad de Navarra, Universidad de Navarra, Pamplona, España.

Endocrinologia Y Nutricion : Organo De La Sociedad Espanola De Endocrinologia Y Nutricion
|April 1, 2014
PubMed
Summary
This summary is machine-generated.

Thyroid autoimmunity was not linked to gestational diabetes (GD) in pregnant women with elevated TSH. However, higher GD prevalence in this group suggests closer monitoring is needed for these pregnancies.

Keywords:
AutoimmunityAutoinmunidadDiabetes gestacionalGestational diabetesHipotiroidismoHypothyroidism

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Area of Science:

  • Endocrinology
  • Immunology
  • Reproductive Medicine

Background:

  • Gestational diabetes (GD) and autoimmune thyroid dysfunction share potential links through pro-inflammatory factors.
  • Understanding the relationship between thyroid autoimmunity and GD is crucial for maternal and fetal health.

Purpose of the Study:

  • To investigate the association between antithyroid antibodies and the development of gestational diabetes (GD).
  • To assess if thyroid autoimmunity influences GD occurrence in pregnant women with elevated TSH.

Main Methods:

  • Retrospective study of 56 pregnant women with first-trimester TSH ≥ 2.5 mU/mL.
  • Measurement of antithyroid antibodies and performance of the O'Sullivan test.
  • Diagnosis of GD based on Spanish Group on Diabetes and Pregnancy criteria.

Main Results:

  • Antithyroid antibodies were present in 37.50% of women.
  • GD was diagnosed in 15 patients; 6 had positive antibodies, 9 had negative antibodies.
  • No statistically significant difference in GD occurrence between patients with positive and negative autoimmunity (OR = 1.15; P = 1.00).

Conclusions:

  • Thyroid autoimmunity is not associated with GD development in pregnant women with TSH ≥ 2.5 mU/mL.
  • GD prevalence was higher in this cohort compared to the general Spanish population.
  • Closer monitoring is recommended for pregnant women with TSH levels ≥ 2.5 mU/mL.