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Proteasome activation delays aging in vitro and in vivo

Niki Chondrogianni1, Marianthi Sakellari2, Maria Lefaki1

  • 1National Hellenic Research Foundation, Institute of Biology, Medicinal Chemistry, and Biotechnology, 116 35 Athens, Greece.

Free Radical Biology & Medicine
|April 1, 2014
PubMed

Insights

Activating the proteasome, a cellular cleanup system, significantly slows aging across species. This conserved mechanism involves enhancing protein homeostasis and reducing age-related damage for extended longevity.

Area of Science:

  • Molecular Biology
  • Gerontology
  • Cellular Biology

Background:

  • Aging involves accumulating cellular damage, particularly misfolded proteins.
  • The proteasome is crucial for clearing damaged and misfolded proteins.
  • Declining proteasome function contributes to aging.

Purpose of the Study:

  • To review the function of proteasome activators.
  • To explore how proteasome activation regulates aging.
  • To highlight the evolutionary conservation of this mechanism.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of studies on proteasome activation in various species.
  • Examination of genetic and compound-based activation methods.

Main Results:

  • Proteasome activation, through genetic or chemical means, retards aging.
  • This effect is observed across different species, indicating evolutionary conservation.
  • Proteasome activators improve protein homeostasis and reduce macromolecular damage.

Conclusions:

  • Proteasome activation is a conserved mechanism for regulating aging and longevity.
  • Targeting the proteasome offers a promising strategy for interventions against aging.
  • Understanding proteasome function is key to developing anti-aging therapies.
Keywords:
AgingFree radicalsLongevity regulationProteasome activationSenescenceUbiquitin–proteasome system

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