Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reliability of minute ventilation as a parameter for rate responsive pacing.

C P Lau1, A Antoniou, D E Ward

  • 1Department of Cardiological Sciences, St. George's Hospital Medical School, London.

Pacing and Clinical Electrophysiology : PACE
|February 1, 1989
PubMed
Summary

This study shows that a minute ventilation sensing pacemaker significantly improved exercise capacity and cardiac output in patients with bradycardia. The device appropriately adjusted pacing rates based on physical activity levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Defining Standard Data Reporting in Pelvic Exenterations for Non-Rectal Cancers: A Systematic Review of Current Data Reporting.

Cancers·2025
Same author

Implementation of a clinical pathway for the surgical treatment of colorectal cancer during the COVID-19 pandemic.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2020
Same author

A critical survey of a dedicated craniofacial surgery outpatient's clinic within a public health service structure.

Hellenic journal of nuclear medicine·2019
Same author

Transperineal retropubic approach in total pelvic exenteration for advanced and recurrent colorectal and anal cancer involving the penile base: technique and outcomes.

Techniques in coloproctology·2018
Same author

Selection, drift, and introgression shape MHC polymorphism in lizards.

Heredity·2018
Same author

Educating anesthesia residents to obtain and document informed consent for epidural labor analgesia: does simulation play a role?

International journal of obstetric anesthesia·2018

Area of Science:

  • Cardiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Bradycardia necessitates pacemakers for heart rate regulation.
  • Rate-responsive pacemakers aim to mimic physiological heart rate changes.
  • Minute ventilation sensing offers a novel approach to pacemaker rate modulation.

Purpose of the Study:

  • To evaluate the efficacy of a minute ventilation sensing rate-responsive pacemaker.
  • To assess improvements in exercise capacity and cardiac output.
  • To determine the accuracy and safety of the pacemaker's rate response.

Main Methods:

  • Implantation of a minute ventilation sensing pacemaker in 11 bradycardia patients.
  • Programming simplicity with adjustable upper/lower rates and response slope.

Related Experiment Videos

  • Symptom-limited treadmill tests comparing VVI and rate-responsive modes.
  • Noninvasive assessment of cardiac output using Doppler echocardiography.

    • Main Results:

    • A 33% improvement in exercise capacity and 44% increase in cardiac output were observed.
    • Pacing rate appropriately adjusted during daily activities like walking and stair climbing.
    • Voluntary respiratory maneuvers affected pacing rate, but excessive acceleration was not observed.
    • The pacemaker detected activity from arm swinging.

    Conclusions:

    • The Meta pacemaker effectively enhanced cardiac output and exercise capacity in bradycardia patients.
    • The device's rate response correlated with patient workload.
    • While susceptible to respiratory interference, the pacemaker demonstrated a safe rate response profile.