[Tissue fixation in clinical practice: the 120-year-old formalin]
1Debreceni Egyetem, Általános Orvostudományi Kar Pathologiai Intézet Debrecen Nagyerdei krt. 98. 4032.
Abstract:
Formalin, the saturated watery solution of formaldehyde is used in every health care institution worldwide as an effective and cheap tissue fixative. The beneficial effect of the formaldehyde solution was discovered and published exactly 120 years ago and, despite significant technological developments, the formula is still used in the same way. However, tissue based molecular techniques including multiple gene mutation testing from isolated DNA require a highly standardized tissue preservation procedure and the strict control of the composition of the fixative solution applied.
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