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Related Experiment Video

Updated: May 1, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans

Published on: January 8, 2015

Prion protein and cancers.

Xiaowen Yang¹, Yan Zhang², Lihua Zhang³

¹Department of the First Abdominal Surgery, Jiangxi Tumor Hospital, Nanchang 330029, China.

Acta Biochimica Et Biophysica Sinica

|April 1, 2014

Summary

The normal cellular prion protein (PrP(C)) is vital for mammals but its function is unclear. This review explores PrP(C)

Keywords:

prion disease prion protein tumorigenesis

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Area of Science:

Biochemistry
Cell Biology
Neuroscience

Background:

The normal cellular prion protein (PrP(C)) is a conserved cell surface glycoprotein found in mammals.
While its role in prion diseases is established, the physiological functions of PrP(C) are not fully understood.
Numerous functions have been proposed for PrP(C) based on cell model studies.

Purpose of the Study:

To review the potential roles of PrP(C) in normal cell physiology.
To focus on the contribution of PrP(C) to tumorigenesis.

Main Methods:

Literature review of existing studies on PrP(C) function.
Analysis of cell model data investigating PrP(C) roles.
Synthesis of findings related to PrP(C) and cancer development.

Main Results:

PrP(C) is implicated in various cellular processes, including cell adhesion, signal transduction, and copper metabolism.
Emerging evidence suggests a role for PrP(C) in the regulation of cell proliferation, differentiation, and apoptosis.
Studies indicate that PrP(C) expression is altered in several types of tumors and may influence tumor growth and metastasis.

Conclusions:

PrP(C) likely plays multifaceted roles in normal cell physiology.
The involvement of PrP(C) in tumorigenesis warrants further investigation.
Understanding PrP(C) functions could offer new insights into cancer biology and potential therapeutic strategies.