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Using positron emission tomography to study transporter-mediated drug-drug interactions in tissues
B Wulkersdorfer1, T Wanek2, M Bauer1
1Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Abstract:
Drug disposition is highly regulated by membrane transporters. Some transporter-mediated drug-drug interactions (DDIs) may not manifest themselves in changes in systemic exposure but rather in changes in tissue exposure of drugs. To better assess the impact of transporter-mediated DDIs in tissues, positron emission tomography (PET)-a noninvasive imaging method--plays an increasingly important role. In this article, we provide examples of how PET can be used to assess transporter-mediated DDIs in different organs.
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