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Updated: May 1, 2026

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
Everything you need to know about distal renal tubular acidosis in autoimmune disease
Tim Both1, Robert Zietse, Ewout J Hoorn
1Division of Clinical Immunology, Department of Internal Medicine, Erasmus Medical Centre, PO Box 2040, Room D-XXX, 3000 CA, Rotterdam, The Netherlands, t.both.1@erasmusmc.nl.
Abstract:
Renal acid-base homeostasis is a complex process, effectuated by bicarbonate reabsorption and acid secretion. Impairment of urinary acidification is called renal tubular acidosis (RTA). Distal renal tubular acidosis (dRTA) is the most common form of the RTA syndromes. Multiple pathophysiologic mechanisms, each associated with various etiologies, can lead to dRTA. The most important consequence of dRTA is (recurrent) nephrolithiasis. The diagnosis is based on a urinary acidification test. Potassium citrate is the treatment of choice.
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