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Flavonoids in modulation of cell survival signalling pathways
Mohammad Lukman Mansuri1, Priyanka Parihar, Isha Solanki
1School of Studies in Zoology and Biotechnology, Vikram University, Ujjain, MP, India.
Genes & Nutrition
|April 1, 2014
Summary
Flavonoids, found in fruits and vegetables, offer health benefits beyond antioxidant effects. These compounds modulate cellular signaling pathways, impacting cell function and gene expression for disease prevention.
Area of Science:
- Nutritional Science
- Molecular Biology
- Cellular Biology
Background:
- Flavonoids are polyphenols abundant in fruits, vegetables, and beverages like tea and red wine.
- Emerging research highlights flavonoids' potential in preventing chronic disorders, including neuroprotective, cardioprotective, anti-inflammatory, and chemopreventive roles.
- While antioxidant properties are well-known, recent focus is on flavonoids' modulatory actions on cellular signaling pathways.
Purpose of the Study:
- To provide an overview of flavonoids' role in modulating cellular survival signaling pathways.
- To explore mechanisms beyond conventional antioxidant activity.
Main Methods:
- Literature review of studies on flavonoid mechanisms of action.
- Analysis of research on flavonoid interactions with key cellular signaling pathways.
- Examination of flavonoid effects on gene expression and transcription factors.
Main Results:
- Flavonoids and their metabolites act as more than just antioxidants.
- They directly modulate crucial signaling pathways, including PI3K/Akt, MAPK, tyrosine kinases, and PKC.
- Flavonoids influence cellular functions by altering protein phosphorylation and modulating gene expression via transcription factors.
Conclusions:
- Flavonoids play a significant role in cellular survival signaling.
- Their impact on cellular pathways and gene expression contributes to their health benefits.
- Further research into these mechanisms can inform nutritional strategies for disease prevention.
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